The goal of the 16th IEEE/ASME MESA 2020 is to bring together experts from the fields of mechatronic and embedded systems, disseminate the recent advances in the area, discuss future research directions, and exchange application experience. MESA 2020 will especially bring out and highlight the latest research results and development in Industry 4.0 and Artificial Intelligence (AI) in the fields of mechatronics and embedded systems.